Bange Lab - N-terminal processing and degradation

Research Topics

• N-terminal acetylation and protein destabilization
• N-degrons and protein quality control
• Connection between N-terminal acetylation and metabolism
• Mass Spectrometry-based quantitative proteomics

As a protein’s nascent chain emerges from a translating ribosome, its N-terminus undergoes various modifications. Most common are the acetylation of the initiator N-terminal methionine (iMet), or its removal by methionine-aminopeptidases (MetAPs), exposing the second amino acid, often followed by sequence-specific acetylation of the newly generated N-terminus. Less common are N-terminal (Nt-) myristoylation, Nt-metylation, and Nt-arginylation. Our work focuses on N-terminal acetylation and its role for protein degradation/protein quality control and its interplay with metabolism.

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Selected Publications

Christoph Schmal 1 , Bert Maier 2 , Reut Ashwal-Fluss 3 , Osnat Bartok 3 , Anna-Marie Finger 2 , Tanja Bange 4 , Stella Koutsouli 4 , Maria S Robles 4 , Sebastian Kadener 3 5 , Hanspeter Herzel 1 , Achim Kramer 2 Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock https://pubmed.ncbi.nlm.nih.gov/37532409/

Sing D., Schmidt N., Mueller F., Bange T., Bird, AW. Destabilization of Long Astral Microtubules via a Cdk1-Dependent Removal of GTSE1 from Their Plus Ends Facilitates Prometaphase Spindle Orientation. (2021) Curr Biol, Feb 22; 31(4):766-781.e8. doi: 10.1016/j.cub2020.11.040. Current Biology

Mueller, F., Friese, A., Pathe, C., Cardoso da Silva, R., Bravo Rodriguez, K., Musacchio A. *, Bange, T.* Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization. (2021). Sci Adv, Jan 7;3 doi:10.1126/sciadv.abc8590 *co-corresponding authors. Science Advances

Singh, P., Pesenti, M., Maffini, S., Carmignani, S., Hedtfeld, M., Petrovic, A., Srinivasamani, A., Bange, T., Musacchio, A., BUB1 and CENP-U primed by CDK1, are the main PLK1 kinetochore receptors in mitosis. (2021) Mol Cell, Jan 7;81(1):67-87e9. doi: 10.1016/j.molcel.2020.10.040. Molecular Cell

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