Institute of Medical Psychology

Breadcrumb Navigation


Robles Lab - Publications

2023  2022   |   2021   |   2020   |   2019   |   2018   |   2017   |   2016   |   2015   |   2014   |   2013   |   2012   |   2011   |   2010   |   2003   |   2002   |   2000 and before



Schmal C, Maier B, Ashwal-Fluss R, Bartok O, Finger AM, Bange T, Koutsouli S, Robles MS, Kadener S, Herzel H, Kramer A. Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock. PLoS Biol. 2023 Jun 28;21(6):e3002164. doi: 10.1371/journal.pbio.3002164

Paul MC, Schneeweis C, Falcomatà C, ... Robles MS, ..., Andrieux G, Boerries M, Rad R, Schneider G and Saur D. (2023) Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun.



Perseus plugin "Metis" for metabolic-pathway-centered quantitative multi-omics data analysis for static and time-series experimental designs
Hamid Hamzeiy 1 , Daniela Ferretti 1 , Maria S Robles 2 , Jürgen Cox 1 3. Pubmed

Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition.
Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D, Schneider G. Pubmed

Kliem FP, Brüning F, Robles MS (2022) Proteomics Approaches to Assess Sleep and Circadian Rhythms. Circadian Clocks. Neuromethods 4_15

Hamzeiy H, Ferretti D, Robles MS*, and Cox J*. (2022) Perseus plugin ‘Metis’ for metabolic pathway-centered quantitative multi-omics data analysis supporting static and time-series experimental designs. Cell Reports Methods. *co- corresponding author.

Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D and Schneider G. (2022) Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition. Cancer Commun. doi:10.1002/cac2.12280

Falcomatà, C, Bärthel, S, Widholz, SA, ...Robles MS, ..., Schneider G and Saur D. (2022) Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. doi: 10.1038/s43018-021-00326-1


Falcomatà C, Bärthel S, Ulrich A, S Diersch, …Robles MS, …, Schneider G and Saur D. (2021) Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer. Cancer Discov., 2021 Jul 19;. doi: 10.1158/2159-8290.CD-21-0209. PubMed

Hansen FM, Tanzer MC, Brüning F, Bludau I, Stafford C, Schulman BA, Robles MS*, Karayel O*, Mann M*. (2021) Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nat Commun. Jan 11;12(1):254. *co-corresponding author. PubMed


Brüning F, Humphrey SJ, Robles MS (2020) Phosphoproteome and Proteome Sample Preparation from Mouse Tissues for Circadian Analysis. Methods Mol Biol.; 2130:185-193.Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons. PubMed



Brüning F, Noya SB, Bange T, Koutsouli S, Rudolph JD, Tyagarajan SK, Cox J, Mann M, Brown SA*, Robles MS*. (2019) Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. Oct 11;366(6462). *co-corresponding author. PubMed

Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK*, Robles MS*, Brown SA*. (2019) The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science. Oct 11;366(6462). *co-corresponding author. PubMed. 

Harpprecht L, Baldi, S, Schauer T, Schmidt A, Bange T, Robles MS, Kremmer E, Imhof A and Becker PB. (2019) A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Nucleic Acids Res. May 31. PubMed



Korge S, Maier, B, Brüning, F, Ehrhardt, L, Korte, T, Mann, M, Herrmann, A, Robles MS and Kramer A. (2018) The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization. PLoS Genet. Jan 29;14(1): e1007189. PubMed



Hughes ME,… Robles MS,…, Hogenesch JB. (2017) Guidelines for genome-scale analysis of biological rhythms. J Biol Rhythms Oct;32(5):380-393. PubMed

Robles MS, Humphrey SJ and Mann M. (2017) Central role of phosphorylation in the circadian control of liver metabolism. Cell Metab Jan 10;25(1):118-127. PubMed



Neufeld-Cohen A*, Robles MS*#, Adamovich Y, Nir D, Rousso-Noori L, Yael Kuperman Y, Golik M, Mann M and Asher G#. (2015) Circadian control of mitochondrial nutrient utilization through regulation of rate-limiting mitochondrial enzymes. Proc Natl Acad Sci USA, Mar 22;113(12):E1673-82 doi:10.1073 *Equal contribution; # corresponding authors. PubMed



Tamayo AG, Duong HA, Robles MS, Mann M, Weitz CJ. (2015) Histone mono-ubiquitination by a Clock–Bmal1 complex marks circadian clock genes for feedback repression. Nat Struct Mol Biol, Oct; 22(10):759-66. PubMed



Robles MS, Cox J, Mann M. (2014) In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet. Jan; 10(1): e1004047. PubMed



Robles MS, Mann M. (2013) Proteomic approaches in circadian biology. Handb Exp Pharmacol.; (217): 389-407  PubMed



Padmanabhan K, Robles MS, Westerling T, Weitz CJ. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. Aug 3; 337 (6094): 599-602. PubMed



Duong HA*, Robles MS*, Knutti D, Weitz CJ. (2011) A molecular mechanism for circadian clock negative feedback. Science. Jun 17; 332 (6036): 1436-9. *Equal contribution.  PubMed



Robles MS*, Boyault C*, Knutti D*, Padmanabhan K, Weitz CJ. (2010) Identification of RACK1 and protein kinase C alpha as integral components of the mammalian circadian clock. Science. Jan 22; 327 (5964): 463-6. *Equal contribution  PubMed

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. Pfaller CK, Conzelmann KK.
J Virol. 2008 Dec;82(24):12365-73. doi: 10.1128/JVI.01321-08. Epub 2008 Oct 15. PubMed

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.
Cui S, Eisenächer K, Kirchhofer A, Brzòzka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.
Mol Cell. 2008 Feb 1;29(2):169-79. doi: 10.1016/j.molcel.2007.10.032. PubMed

Double-labeled rabies virus: live tracking of enveloped virus transport.
Klingen Y, Conzelmann KK, Finke S.
J Virol. 2008 Jan;82(1):237-45. Epub 2007 Oct 10. PubMed



Robles MS, Leonardo EM, Izquierdo M and Martínez-A C. (2003) Exacerbated inflammatory responses in transgenic mice expressing an inhibitor of apoptosis protein (OpIAP). Cell Death and Differ. 10 (11): 1226-33. PubMed

Moreno de Alboran I, Robles MS, Bras A, Baena E and Martinez-AC. (2003) Cell death during lymphocyte development and activation. Seminars in Immunology, (15) 4: 121-199. PubMed



del Prete MJ, Robles MS, Guio A, Martinez-AC, Izquierdo M, and Garcia-Sanz JA. (2002) Degradation of cellular mRNA is a general early apoptosis-induced event. FASEB J, 14: 2003-5. PubMed

Robles MS, Leonardo E, Criado LM, Izquierdo M. and Martínez-AC. (2002) OpIAP provides a costimulatory signal required for optimal proliferation of developing thymocytes. Journal of Immunology, 168: 1770-1779. PubMed


2000 and before

Izquierdo M, Grandien A, Criado LM, Robles S, Leonardo E, Albar JP, de Buitrago GG and Martinez-AC. (1999) Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor. EMBO J, 18: 156-166. PubMed

Revilla V, Robles MS, Bermejo JC, Paniagua MA, Fernandez-Lopez A. (1999) Seizure-refractory period after a single stimulation and inhibition of seizures after repetitive stimulation in the gerbil: effects on blood cortisol levels. Epilepsia, 40(1): 1-4. PubMed