Publications
selection of recent publications:
Systems Chronobiology Lab - Prof. Maria Robles and colleagues
2023
Schmal C, Maier B, Ashwal-Fluss R, Bartok O, Finger AM, Bange T, Koutsouli S, Robles MS, Kadener S, Herzel H, Kramer A. Alternative polyadenylation factor CPSF6 regulates temperature compensation of the mammalian circadian clock. PLoS Biol. 2023 Jun 28;21(6):e3002164. doi: 10.1371/journal.pbio.3002164.
Paul MC, Schneeweis C, Falcomatà C, Robles MS, Andrieux G, Boerries M, Rad R, Schneider G and Saur D. (2023) Non-canonical functions of SNAIL drive context-specific cancer progression. Nat Commun. doi.org/10.1038/s41467-023-36505-0
2022
Kliem FP, Brüning F, Robles MS (2022) Proteomics Approaches to Assess Sleep and Circadian Rhythms. Circadian Clocks. Neuromethods doi.org/10.1007/978-1-0716-2577- 4_15
Hamzeiy H, Ferretti D, Robles MS*, and Cox J*. (2022) Perseus plugin ‘Metis’ for metabolic pathway-centered quantitative multi-omics data analysis supporting static and time-series experimental designs. Cell Reports Methods. doi.org/10.1016/j.crmeth.2022.100198. *co- corresponding author.
Schneeweis C, Hassan Z, Ascherl K, Wirth M, Koutsouli S, Orben F, Krauß L, Schneider C, Öllinger R, Krämer OH, Rad R, Reichert M, Robles MS, Saur D and Schneider G. (2022) Indirect targeting of MYC sensitizes pancreatic cancer cells to mechanistic target of rapamycin (mTOR) inhibition. Cancer Commun. doi:10.1002/cac2.12280
Falcomatà, C, Bärthel, S, Widholz, SA, ...Robles MS, ..., Schneider G and Saur D. (2022) Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nat Cancer. doi: 10.1038/s43018-021-00326-1
2021
Hansen FM, Tanzer MC, Brüning F, Bludau I, Stafford C, Schulman BA, Robles MS*, Karayel O*, Mann M*. (2021) Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology. Nat Commun. Jan 11;12(1):254. *co-corresponding author
Brüning F, Humphrey SJ, Robles MS (2020) Phosphoproteome and Proteome Sample Preparation from Mouse Tissues for Circadian Analysis. Methods Mol Biol.; 2130:185-193.
Brüning F, Noya SB, Bange T, Koutsouli S, Rudolph JD, Tyagarajan SK, Cox J, Mann M, Brown SA*, Robles MS*. (2019) Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. Oct 11;366(6462). *co-corresponding author
Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK*, Robles MS*, Brown SA*. (2019) The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science. Oct 11;366(6462). *co-corresponding author
Robles MS, Humphrey SJ and Mann M. (2017) Central role of phosphorylation in the circadian control of liver metabolism. Cell Metab Jan 10;25(1):118-127.
Neufeld-Cohen A*, Robles MS*#, Adamovich Y, Nir D, Rousso-Noori L, Yael Kuperman Y, Golik M, Mann M and Asher G#. (2015) Circadian control of mitochondrial nutrient utilization through regulation of rate-limiting mitochondrial enzymes. Proc Natl Acad Sci USA, Mar 22;113(12):E1673-82 doi:10.1073 *Equal contribution; # corresponding authors
Robles MS, Cox J, Mann M. (2014) In-vivo quantitative proteomics reveals a key contribution of post-transcriptional mechanisms to the circadian regulation of liver metabolism. PLoS Genet. Jan; 10(1): e1004047
Padmanabhan K, Robles MS, Westerling T, Weitz CJ. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. Aug 3; 337 (6094): 599-602
Duong HA*, Robles MS*, Knutti D, Weitz CJ. (2011) A molecular mechanism for circadian clock negative feedback. Science. Jun 17; 332 (6036): 1436-9. *Equal contribution
Robles MS*, Boyault C*, Knutti D*, Padmanabhan K, Weitz CJ. (2010) Identification of RACK1 and protein kinase C alpha as integral components of the mammalian circadian clock. Science. Jan 22; 327 (5964): 463-6. *Equal contribution
Sleep and Immunology Lab - Prof. Luciana Besedovsky and colleagues:
Blaskovich B, Bullón-Tarrasó E, Pöhlchen D, Manafis A, Neumayer H, Besedovsky L, Brückl T; BeCOME Working Group; Simor P, Binder FP, Spoormaker VI.
The utility of wearable headband electroencephalography and pulse photoplethysmography to assess cortical and physiological arousal in individuals with stress-related mental disorders. J Sleep Res. 2023 Dec 15:e14123. doi:10.1111/jsr.14123. Epub ahead of print. PMID: 38099396.
Wilantri S, Grasshoff H, Lange T, Gaber T, Besedovsky L, Buttgereit F.
Detecting and exploiting the circadian clock in rheumatoid arthritis. Acta Physiol (Oxf). 2023 Oct;239(2):e14028. doi: 10.1111/apha.14028. Epub 2023 Aug 23. PMID: 37609862.
Haack M, Engert LC, Besedovsky L, Goldstein MR, Devine JK, Dang R, Olia K, Molina V, Bertisch SM, Sethna N, Simpson N. Alterations of pain pathways by experimental sleep disturbances in humans: central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways. Sleep. 2023 Jun 13;46(6):zsad061. doi: 10.1093/sleep/zsad061. PMID: 36881901; PMCID: PMC10262178.
Miao, X., Müller, C., Lutz, N. D., Yang, Q., Waszak, F., Born, J., & Rauss, K. (2023). Sleep consolidates stimulus–response learning. Learning & Memory, 30(9), 175–184. https://doi.org/10.1101/lm.053753.123
Molecular Chronobiology Lab - Prof. Martha Merrow and colleagues:
Giulia Zerbini 1 2 3, Eva C Winnebeck 1, Martha Merrow 1; Weekly, seasonal, and chronotype-dependent variation of dim-light melatonin onset, Affiliations expand; 2021 Feb 20;e12723.
doi: 10.1111/jpi.12723. Online ahead of print
Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M. (2021) A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care. J Biol Rhythms. Feb 11:748730421992587. doi: 10.1177/0748730421992587
Eelderink-Chen Z, Bosman J, Sartor F, Dodd AN, Kovács ÁT, Merrow M. (2021) Sci-ence Advances; in press: A circadian clock in non-photosynthetic bacteria Sci Adv. Jan 8;7(2):eabe2086. doi: 10.1126/sciadv.abe2086.
Boltze J, Didwischus N, Merrow M, Dallmann R, Plesnila N.J (2020) Circadian effects on stroke outcome - Did we not wake up in time for neuroprotection? Cereb Blood Flow Metab. Dec 18:271678X20978711. doi: 10.1177/0271678X20978711.
Merrow, M., & Harrington, M. (2020). A functional context for heterogeneity of the circadian clock in cells. PLoS Biology, 18(10). https://doi.org/10.1371/journal.pbio.3000927
Zerbini, G., van der Vinne, V., Otto, L. K. M., Monecke, S., Kantermann, T., & Merrow, M. (2019). Tardiness Increases in Winter: Evidence for Annual Rhythms in Humans. Journal of Biological Rhythms. https://doi.org/10.1177/0748730419876781
Sartor F, Eelderink-Chen Z, Aronson B, Bosman J, Hibbert LE, Dodd AN, Ko-vács ÁT, Merrow M. (2019) Are There Circadian Clocks in Non-Photosynthetic Bacteria? Biology (Basel). May 22;8(2). pii: E41. doi: 10.3390/biology8020041.
Zerbini G, Kantermann T, Merrow M. (2018) Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin. Eur J Neurosci. Dec 2. doi: 10.1111/ejn.14293. [Epub ahead of print]
Breit A, Miek L, Schredelseker J, Geibel M, Merrow M, Gudermann T. (2018) Insulin-like growth factor-1 acts as a zeitgeber on hypothalamic circadian clock gene expression via glycogen synthase kinase-3beta signaling.J Biol Chem. Nov 2;293(44):17278-17290. doi: 10.1074/jbc.RA118.004429. Epub 2018 Sep 14.
Olmedo M, Roenneberg T, Merrow M, Corrochano LM. (2017) Glucose sensing and light regulation: A mutation in the glucose sensor RCO-3 modifies pho-toadaptation in Neurospora crassa. Fungal Biol. Jun;122(6):497-504. doi: 10.1016/j.funbio.2017.10.004. Epub 2017 Nov 4.
Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Bio-logical Rhythms. (2017) J Biol Rhythms Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3.
de Bekker, C., Will, I., Hughes, D.P., Brachmann, A. Merrow, M. (2017) Daily rhythms and enrichment patterns in the transcriptome of the behavior-manipulating parasite Ophiocordyceps kimflemingiae PLoSOne Nov 3;12(11):e0187170. doi: 10.1371/journal.pone.0187170. eCollection 2017.
Cognitive Neurosciences Lab, Prof. Dr. Ernst Pöppel and colleagues
Lingyan Wang, Xiaoxiong Lin, Bin Zhou, Ernst Pöppel, Yan Bao (2016). Rubberband Effect in Temporal Control of Mismatch Negativity. Frontiers in Psychology, 7:1299. doi: 10.3389/fpsyg.2016.01299
Bin Zhou, Ernst Pöppel, Lingyan Wang, Taoxi Yang, Yuliya Zaytseva, Yan Bao (2016). Seeing without knowing: Operational principles along the early visual pathway. PsyCh Journal, 5: 145-160. DOI: 10.1002/pchj.141
Yan Bao, Alexandra von Stosch, Mona Park, Ernst Pöppel (2017). Complementarity as Generative Principle: A Thought Pattern for Aesthetic Appreciations and Cognitive Appraisals in General. Frontiers in Psychology. Doi.org/10.3389/fp-syg.2017.00727
von Trott zu Solz, J., Paolini, M., Silveira, S. (2017). Does touch inhibit visual imagery? A case study on acquired blindness. PsyCh Journal, 6, 139-140 doi: 10.1002/pchj.162
Yang T, Strasburger H, Pöppel E, Bao Y (2018) Attentional modulation of speed-change perception in the perifoveal and near-peripheral visual field. PLoS ONE 13(8): e0203024. https:// doi.org/10.1371/journal.pone.0203024
Koji Tanida, Marco Paolini, Ernst Pöppel, Sarita Silveira (2018): Safety feelings and anticipatory control: An fMRI study on safety and risk perception. Transportation Research Part F: Traffic Psychology and Behavior, https://doi.org/10.1016/j.trf.2018.02.020
Xiang Li, Ernst Pöppel, Yan Bao (2018): A nonparametric method to detect oscillatory components in short time series. PsyCh Journal, DOI: 10.1002/pchj.221
Ernst Pöppel (2018): East of West, West of East: a matter of global and local identity. Cognitive Prcessing. doi.org/10.1007/s10339-018-0885-2
Taoxi Yang, Sarita Silveira, Arusu Formuli, Marco Paolini, Ernst Pöppel, Tilmann Sander, Yan Bao (2019). Aesthetic experiences across cultures: neural correlates when viewing traditional Eastern or Western landscape paintings. Frontiers in Psychology10:798. doi: 10.3389/fpsyg.2019.00798
Taoxi Yang, Xiaoxuan Li, Yao Li, Ernst Pöppel, Yan Bao (2020). Temporal twilight zone and beyond: Timing mechanisms in consciously delayed actions. PsyCh Journal (2020) DOI: 10.1002/pchj.389
Placebo Research Lab, PD Dr. Karin Meissner and colleagues
Jacob, C., Olliges, E., Haile, A., Hoffmann, V., Jacobi, B., Steinkopf, L., Lanz, M., Wittmann, M., Tschöp, M. & Meissner, K. (2023). Placebo effects on nausea and motion sickness are resistant to experimentally-induced stress. Scientific Reports, 13(1), 9908.
Eggers, C., Olliges, E., Boeck, S., Kruger, S., Uhl, W., & Meissner, K. (2023). Exploring Pain, Quality of Life, and Emotional Well-Being in Patients with Advanced Pancreatic Cancer Practicing Spiritual Meditation: A Pilot Study. Complementary Medicine Research, (2023) 30 (4): 289–298.
Meissner, K., von Törne, C., Lutter, D., Hauck, S. M., & Tschöp, M. (2023). Placebos meet proteomics. In: Placebo Effects through the Lens of Translational Research. (Colloca L, Noel J, Franklin PD, et al. eds.) Oxford University Press: 2023, pp. 103-117.
Zimmermann-Viehoff F, Meissner K, Koch J, Weber CS, Richter S & Deter HC (2013): Autonomic effects of suggestive placebo interventions to increase or decrease blood pressure: a randomized controlled trial in healthy subjects. Journal of Psychosomatic Researc. IF 2.839
Linde K, Friedrichs C, Alscher A, Blank W, Schneider A, Fässler M, Meissner K (2013): Use of placebos and non-specific and complementary treatments by German physicians – rationale and development of a questionnaire. Forschende Komplementärmedizin 20:361–367. IF 1.053
Beissner F, Meissner K, Bär KJ, & Napadow V (2013). The Autonomic Brain: An Activation Likelihood Estimation Meta-Analysis for Central Processing of Autonomic Function. The Journal of Neuroscience, 33(25), 10503-10511. IF 6.747
Meissner, K., Fässler, M., Rücker, G., Kleijnen, J., Hróbjartsson, A., Schneider, A., Antes, G., Linde, K. (2013). Differential Effectiveness of Placebo Treatments - A Systematic Review of Migraine Prophylaxis. JAMA Internal Medicine 173(21):1941-1951. IF 13,246
Human Chronobiology Lab - Prof. Dr. Till Roenneberg and colleagues:
2023
Ghotbi N, Rabenstein A, Pilz LK, Rüther T, Roenneberg T. Chronotype, So-cial Jetlag, and Nicotine Use. Journal of Biological Rhythms.
2023;38(4):392-406. doi:10.1177/07487304231177197
1. Roenneberg, T. Von Türhöhen, Vögeln und starren Gesellschaftssystemen. Schlaf 1–6 (2013).
2. Roenneberg, T. The human sleep project. Nature 498, 427–428 (2013).
3. Roenneberg, T. & Allebrandt, K. V. Genetic approaches to understanding circadian entrainment. Shaw Book 1–9 (2013).
4. Genzel, L. et al. Sleep timing is more important than sleep length or quality for medical school performance. Chronobiol Int 00, 1–6 (2013).
5. Blautzik, J. et al. Classifying fMRI-derived resting-state connectivity patterns according to their daily rhythmicity. NeuroImage 71, 298–306 (2013).
6. Juda, M., Vetter, C. & Roenneberg, T. Chronotype Modulates Sleep Duration, Sleep Quality, and Social Jet Lag in Shift-Workers. J. Biol. Rhythms 28, 141–151 (2013).
7. Juda, M., Vetter, C. & Roenneberg, T. The Munich ChronoType Questionnaire for Shift-Workers (MCTQShift). J. Biol. Rhythms 28, 130–140 (2013).
8. Allebrandt, K. V. et al. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry 18, 122–132 (2013).
9. Roenneberg, T., Kantermann, T., Juda, M., Vetter, C. & Allebrandt, K. V. in Handbook of Experimental Pharmacology 217, 311–331 (Springer Berlin Heidelberg, 2013)
10. Foster, R. G. et al. in Progress in Molecular Biology and Translational Science 119, 325–346 (Elsevier, 2013).