Robles Lab - Research
The circadian clock is an endogenous timing system that regulates in a daily manner physiological functions and behavior by modulating gene expression and protein function. Circadian control of transcription regulation is widely studied however the understanding of circadian dynamics in protein function is in its infancy. My work in the last years has pioneered the use of mass spectrometry-based quantitative proteomics to study temporal dynamics of protein abundance, cellular localization and post-transcriptional modifications (PTMs). This technology has thus proven instrumental in chronobiology to comprehensively understand post-translational mechanism regulating circadian metabolism and physiology. Our group has acquired a state of the art instrument (Q-Exactive™ HF-X) located at the BMC building (https://www.bmc.med.uni-muenchen.de/index.html) that allows us to study basic circadian molecular mechanism. In addition, our work also focuses in the interplay of metabolic, behavioral and cognitive disorders with circadian asynchrony, a condition frequently associated with modern lifestyle.