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Besedovsky Lab - Publications

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The contribution of sleep to the neuroendocrine regulation of rhythms in human leukocyte traffic.
Lange T, Luebber F, Grasshoff H, Besedovsky LPubmed


Integrin Activation Enables Sensitive Detection of Functional CD4+ and CD8+ T Cells: Application to Characterize SARS-CoV-2 Immunity.
Schöllhorn A, Schuhmacher J, Besedovsky L, Fendel R, Jensen ATR, Stevanović S, Lange T, Rammensee HG, Born J, Gouttefangeas C, Dimitrov S. Pubmed


Human sleep consolidates allergic responses conditioned to the environmental context of an allergen exposure.
Besedovsky L, Benischke M, Fischer J, Yazdi AS, Born J. PubMed


The Sleep-Immune Crosstalk in Health and Disease.
Besedovsky L, Lange T, Haack M PubMed

Gαs-coupled receptor signaling and sleep regulate integrin activation of human antigen-specific T cells.
Dimitrov S, Lange T, Gouttefangeas C, Jensen ATR, Szczepanski M, Lehnnolz J, Soekadar S, Rammensee HG, Born J, Besedovsky L. PubMed. 



Activated integrins identify functional antigen-specific CD8+ T cells within minutes after antigen stimulation.
Dimitrov S, Gouttefangeas C, Besedovsky L, Jensen ATR, Chandran PA, Rusch E, Businger R, Schindler M, Lange T, Born J, Rammensee HG. PubMed

Signs of enhanced sleep and sleep-associated memory processing following the anti-inflammatory antibiotic minocycline in men.
Besedovsky L, Schmidt EM, Linz B, Diekelmann S, Lange T, Born J. Pubmed



Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function.
Besedovsky L, Ngo HV, Dimitrov S, Gassenmaier C, Lehmann R, Born J. PubMed



Nocturnal sleep uniformly reduces numbers of different T-cell subsets in the blood of healthy men.
Besedovsky L, Dimitrov S, Born J, Lange T. PubMed



Sleep, Don't Sneeze: Longer Sleep Reduces the Risk of Catching a Cold.
Besedovsky L, Born J. PubMed

Emotional memory can be persistently weakened by suppressing cortisol during retrieval.
Rimmele U, Besedovsky L, Lange T, Born J. Pubmed



Differential acute effects of sleep on spontaneous and stimulated production of tumor necrosis factor in men.
Dimitrov S, Besedovsky L, Born J, Lange T. PubMed

Cortisol increases CXCR4 expression but does not affect CD62L and CCR7 levels on specific T cell subsets in humans.
Besedovsky L, Linz B, Dimitrov S, Groch S, Born J, Lange T. Pubmed

Dopamine D2-like receptor activation wipes out preferential consolidation of high over low reward memories during human sleep.
Feld GB, Besedovsky L, Kaida K, Münte TF, Born J. Pubmed

Mineralocorticoid receptor signaling reduces numbers of circulating human naïve T cells and increases their CD62L, CCR7, and CXCR4 expression.
Besedovsky L, Linz B, Born J, Lange T. Pubmed



Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T-cell subset numbers and the expression of the chemokine receptor CXCR4.
Besedovsky L, Born J, Lange T. PubMed



Blockade of mineralocorticoid receptors enhances naïve T-helper cell counts during early sleep in humans.
Besedovsky L, Born J, Lange T.PubMed